Zydelig Dosage: Form, Strengths, How to Take, and More
Zydelig (idelalisib) is a prescription drug used to treat chronic lymphocytic leukemia (CLL). The drug comes as an oral tablet that’s typically taken twice per day.
Zydelig is prescribed to treat relapsed CLL in adults. It’s taken together with Rituxan (rituximab) in people who are able to take rituximab on its own.
Zydelig belongs to a group of drugs called kinase inhibitors and contains the active ingredient idelalisib. (An active ingredient is what makes a drug work.)
This article describes Zydelig’s dosage, as well as its strengths and how to take it. To learn more about Zydelig, see this in-depth article.
Boxed warnings
Zydelig has boxed warnings about the risk of liver problems, colitis and severe diarrhea, intestinal perforation, pneumonitis, and serious infection. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). It alerts doctors and patients about drug effects that may be dangerous.
Liver problems: Treatment with Zydelig may cause serious liver problems. In rare cases, it may even cause death. Your doctor will monitor your liver function before and during your treatment with Zydelig. They may pause your treatment, adjust your dose, or stop your treatment if needed.
Colitis and severe diarrhea: Zydelig can cause colitis (an inflammation of the colon) and severe diarrhea. In rare cases, this may be life-threatening. Tell your doctor immediately if you have frequent bowel movements, abdominal pain, cramping, blood in your stools, chills, or a fever. They may pause your treatment, adjust your dose, or stop your treatment if needed.
Intestinal perforation: Treatment with Zydelig can cause an intestinal perforation (hole in your intestine). In rare cases, this could cause death. Tell your doctor right away if you have severe diarrhea, nausea, vomiting, fever, or chills. They’ll likely stop your treatment with Zydelig if you have an intestinal perforation.
Pneumonitis: Taking Zydelig may cause pneumonitis (lung inflammation). This is a serious condition that may cause death in rare cases. Your doctor will monitor you for signs of pneumonitis during your Zydelig treatment. Tell them if you have symptoms such as cough, shortness of breath, fever, or chills.
In certain cases, your doctor may prescribe a corticosteroid if you have pneumonitis. They’ll likely also have you stop Zydelig treatment.
Risk of serious infection: Treatment with Zydelig and Rituxan or certain other medications may cause a serious or even fatal infection. Tell your doctor if you have signs of infection, such as a fever. If you develop an infection, your doctor may pause your Zydelig treatment and treat the infection. They’ll then determine whether you should continue taking Zydelig.
What is Zydelig’s dosage?
This section describes the usual dosage of Zydelig.
What is Zydelig’s form?
Zydelig comes as an oral tablet.
What strengths does Zydelig have?
Zydelig comes in two strengths: 100 milligrams (mg) and 150 mg.
What’s the usual dosage of Zydelig?
The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.
Dosage for CLL
The typical Zydelig dosage for adults with relapsed CLL is 150 mg taken twice per day. Zydelig is taken in combination with Rituxan (rituximab) treatment.
You’ll likely take Zydelig until your condition worsens or you cannot tolerate the medication.
If you have questions about your dosage, talk with your doctor.
* Rituxan comes as a liquid solution given as an intravenous (IV) infusion (an injection into a vein given over time). You’ll receive Rituxan infusions from a healthcare professional in a clinic, doctor’s office, or hospital.
Is Zydelig used long-term?
Yes, Zydelig is usually a long-term treatment. If you and your doctor determine that it’s safe and effective for your condition, you’ll likely take it long-term.
What factors can affect my dosage?
The dosage of Zydelig you’re prescribed may depend on several factors. These include:
How is Zydelig taken?
Zydelig comes as an oral tablet. You can take it with or without food. Do not cut, crush, or chew Zydelig tablets. Swallow them whole. If you have trouble swallowing tablets, see this article for tips on how to take this form of medication.
For information on the expiration, storage, and disposal of Zydelig, talk with your doctor or pharmacist.
Accessible drug containers and labels
Some pharmacies provide medication labels that:
Your doctor or pharmacist may be able to recommend pharmacies that offer these accessibility features if your current pharmacy doesn’t.
Let your pharmacist know if you have trouble opening medication bottles. They may have tips to help, or they may be able to supply Zydelig in an easy-to-open container.
What if I miss a dose?
If you miss a dose of Zydelig, take it as soon as you remember. But if it’s been 6 hours or more since your missed dose, skip the missed dose and take your next scheduled dose at its usual time. If you’re not sure whether you should take a missed dose, talk with your doctor or pharmacist.
If you need help remembering to take your dose of Zydelig on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.
What should be done in case of overdose?
Do not take more Zydelig than your doctor prescribes, as this can lead to harmful effects.
What to do in case you take too much Zydelig
Call your doctor right away if you think you’ve taken too much Zydelig. You can also call 800-222-1222 to reach America’s Poison Centers or use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.
Frequently asked questions
Below are answers to some commonly asked questions about Zydelig’s dosage.
Is Zydelig’s dosage similar to that of Venclexta?
No. Both Zydelig and Venclexta (venetoclax) are prescribed to treat CLL (and Venclexta is used to treat other types of cancer). Both drugs come as oral tablets, but they have different active ingredients. (An active ingredient is what makes a drug work.) And the dose in milligrams and dosing schedules for the two drugs differ.
Talk with your doctor to learn more about how these drugs compare. They’ll prescribe the best drug and dosage for treating your condition.
How long does it take for Zydelig to start working?
Zydelig starts to work after your first dose. But because of how it works, you likely won’t feel the drug working in your body. Your doctor will monitor you during treatment to make sure the drug is effectively treating your condition.
If you have other questions about what to expect from your Zydelig treatment, talk with your doctor.
What should I ask my doctor?
The sections above describe the usual dosage provided by Zydelig’s manufacturer. If your doctor recommends this drug, they’ll prescribe the dosage that’s right for you.
Do not change your dosage of Zydelig without your doctor’s recommendation. Only take this drug exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage. Examples of questions you may want to ask include:
This article provides very detailed and clear information about Zydelig dosage. It’s extremely helpful to understand the various forms and strengths available, along with precise instructions on how to take it. Overall, a great resource for anyone looking to know more about this medication! Thanks for sharing!
Great read! The breakdown of Zydelig’s dosage forms and strengths was very helpful. The detailed instructions on how to take it and what to expect were also clear and informative. Thanks for putting this together!
This is a very informative and comprehensive guide on Zydelig dosage! I appreciate the clear breakdown of form, strengths, and instructions on how to take it. It’s incredibly useful for anyone prescribed this medication and looking for detailed information. Thank you for sharing!
Great post! Very informative and easy to understand. I appreciate the detailed explanations on the different dosages and strengths of Zydelig, as well as the clear instructions on how to take it. This information is incredibly helpful for patients and caregivers alike. Thanks for sharing! 🌟