Vyvgart dosage: Form, strength, how to use, and more
Vyvgart (efgartigimod alfa-fcab) is prescribed to treat myasthenia gravis in adults. A healthcare professional gives the drug by intravenous (IV) infusion into a vein. Your dosage and dosing schedule can vary based on certain factors.
Vyvgart is used in adults to treat generalized myasthenia gravis (gMG). It’s used in people who are positive for the anti-acetylcholine receptor (AChR) antibody. (Acetylcholine is a brain chemical that’s important for muscle and brain function. Being positive for the AChR antibody means you have that antibody.)
The active ingredient in Vyvgart is efgartigimod alfa-fcab. Vyvgart is a biologic drug, which is made from living cells. It belongs to a group of drugs called neonatal Fc receptor blockers.
This article describes Vyvgart’s dosages and dosing schedule, which are also discussed in the prescribing information. You can learn about the drug’s cost, side effects, and more in this comprehensive article.
If you’d like to learn about Vyvgart Hytrulo, talk with your doctor. This drug differs from Vyvgart.
What is Vyvgart’s dosage?
This section describes the usual dosages of Vyvgart. Keep reading to learn more.
What is Vyvgart’s form?
Vyvgart is available as a liquid solution. A healthcare professional gives it as an IV infusion. This is an injection into your vein over a period of time.
What strength does Vyvgart come in?
Vyvgart comes in one strength of 400 milligrams per 20 milliliters (mg/mL). Some healthcare professionals refer to this strength as 20 mg/mL.
What are the usual dosages of Vyvgart?
Your doctor will start by prescribing the recommended dosage of Vyvgart to treat your condition.
The information below describes dosages that are commonly used or recommended. Your doctor will determine the best dosage to fit your needs. In some cases, doctors may adjust your dosage from those shown below.
Dosage for generalized myasthenia gravis (gMG)
Vyvgart is used in adults to treat gMG. Your dosage is based on your body weight in kilograms (kg). For reference, 1 kg is about 2.2 pounds (lb).
The typical starting dosage of Vyvgart is typically 10 mg per kg weekly for 4 weeks. For example, if you weigh 90 kg (about 198 lb), your dosage is 900 mg of Vyvgart. Your infusion will be given over 1 hour.
If you weigh 120 kg (about 264 lb) or more, your dosage is 1,200 mg weekly for 4 weeks. Your infusion will be given over 1 hour.
With Vyvgart, a 4-week period is a treatment cycle. (You’ll receive one dose weekly for 4 weeks.) After your first treatment cycle, your doctor will determine your remaining Vyvgart dosing schedule. They’ll base this on how you respond to treatment, how well you handle the medication, and other factors.
Talk with your doctor if you have questions about your dose or your dosing schedule.
Is Vyvgart used long term?
It might be. You’ll typically receive Vyvgart once weekly for 4 weeks. This is a treatment cycle. After your first treatment cycle, your doctor will determine your Vyvgart dosing schedule for future doses if you need them.
Talk with your doctor to learn more about how long you’re likely to receive Vyvgart treatment.
You’ll receive Vyvgart by IV infusion over 1 hour. Your doctor will discuss your Vyvgart infusion protocol (how it’s given). They’ll also calculate your dosage based on your body weight. You’ll receive doses of Vyvgart at a doctor’s office, a clinic, or a hospital.
It typically takes about 1 hour to receive a dose of Vyvgart. Your doctor or another healthcare professional will monitor you closely during your Vyvgart infusion. For example, they’ll check your blood pressure, pulse, and temperature during the procedure.
To learn more about your Vyvgart infusion dosing, talk with your doctor. You can also see this detailed information guide from Vyvgart’s drugmaker.
Frequently asked questions
Below are answers to some commonly asked questions about Vyvgart’s dosage.
How long does Vyvgart last?
The effects of a dose of Vyvgart last several days. This is why you receive a dose only once per week.
In studies, it took about 80 to 120 hours for half of a dose of the drug to leave the body. This is about 3 to 5 days.
If you’d like to learn more about this, talk with your doctor.
Is there a Vyvgart dosing calculator?
Your doctor will use a calculator to determine your dose of Vyvgart based on your body weight in kg. (For reference, 1 kg is about 2.2 lb.)
The typical dose is 10 mg per kg of body weight. So if you weigh 100 kg (about 220 lb), the dose is 1,000 mg. If you weigh 120 kg (about 264 lb) or more, the dose is 1,200 mg. And if you weigh 130 kg (about 286 lb), the dose is 1,200 mg.
You’ll typically receive your dose once weekly for 4 weeks. After that, your doctor will determine your remaining dosing schedule.
If you have questions about your Vyvgart dosage, talk with your doctor to learn more.
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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What forms does Vyvgart come in?
Vyvgart is typically available in an injectable form, specifically designed for intravenous administration. It is important to follow healthcare provider guidance on its use.
What is the typical strength of Vyvgart?
The typical strength of Vyvgart is determined by the healthcare professional and is based on the specific needs of the patient. Always refer to the prescription details provided by your doctor for precise information.
How should I use Vyvgart?
Vyvgart should be used exactly as prescribed by your healthcare provider. It is generally administered through an intravenous infusion, which should be conducted in a medical setting to ensure safety.
How often is Vyvgart administered?
The frequency of Vyvgart administration depends on individual treatment plans tailored by a healthcare provider. Patients should adhere strictly to the schedule provided by their doctor.
Can I administer Vyvgart myself at home?
Vyvgart is typically administered in a healthcare setting due to the need for professional monitoring. Self-administration is not recommended unless explicitly instructed and trained by a healthcare professional.
What should I do if I miss a dose of Vyvgart?
If you miss a dose of Vyvgart, contact your healthcare provider for advice on the next steps. Do not attempt to double up or take extra doses without consulting a medical professional.
Are there any side effects associated with Vyvgart?
As with any medication, Vyvgart may cause side effects. It’s essential to discuss potential risks with your healthcare provider and report any unusual symptoms immediately.
Where can I find more information about Vyvgart?
For more detailed information about Vyvgart, including usage guidelines and potential side effects, consult with your healthcare provider or visit reputable medical websites.
