Nurtec ODT Interactions: Alcohol, Medications, and Others

Nurtec ODT (rimegepant) is a prescription drug used to treat and prevent migraine in adults. The drug can interact with some supplements and other medications, such as certain antibiotics and antiepileptic drugs.

Does Nurtec ODT interact with other drugs?

An interaction can occur because one substance causes another substance to have a different effect than expected. Interactions can also occur if you have certain health conditions.

Before you start taking Nurtec ODT, tell your doctor and pharmacist about any prescription, over-the-counter, or other drugs you take. Sharing this information with them may help prevent possible interactions. (To learn whether Nurtec ODT interacts with herbs or vitamins and supplements, see the “Are there other interactions with Nurtec ODT?” section below.)

If you have questions about drug interactions that may affect you, talk with your doctor or pharmacist.

The table below lists drugs that may interact with Nurtec ODT. Keep in mind that this table does not include all drugs that may interact with Nurtec ODT. For more information about some of these interactions, see the “Drug interactions explained” section below. You can also ask your pharmacist or doctor for more specifics on what medications should not be taken with Nurtec ODT.

Drug group or drug name	Drug examples	What can happen
certain antiandrogen drugs	• apalutamide (Erleada) • enzalutamide (Xtandi)	can make Nurtec ODT less effective
certain antibiotics	• clarithromycin • erythromycin (Eryc, others)	can increase the risk of side effects from Nurtec ODT
certain antiseizure drugs	• carbamazepine (Tegretol, others) • phenytoin (Dilantin)	can make Nurtec ODT less effective
certain antifungals	• itraconazole (Sporanox, Tolsura) • ketoconazole	can increase the risk of side effects from Nurtec ODT
certain drugs for heart conditions	• amiodarone (Pacerone) • verapamil (Verelan, others)	can increase the risk of side effects from Nurtec ODT
cobicistat (Tybost) and combination drugs that contain it	• cobicistat/darunavir/emtricitabine/ tenofovir alafenamide fumarate (Symtuza) • cobicistat/elvitegravir/emtricitabine/ tenofovir alafenamide fumarate (Genvoya)	can increase the risk of side effects from Nurtec ODT
ritonavir (Norvir) and combination drugs that contain it	• nirmatrelvir/ritonavir (Paxlovid) • lopinavir/ritonavir (Kaletra)	can increase the risk of side effects from Nurtec ODT
cyclosporine (Gengraf, Neoral, Sandimmune)	—	can increase the risk of side effects from Nurtec ODT
sofosbuvir/velpatasvir/voxilaprevir (Vosevi)	—	can increase the risk of side effects from Nurtec ODT

When should I avoid Nurtec ODT?

Certain health conditions or other factors could raise your risk of harm if you take Nurtec ODT. In such cases, your doctor may not prescribe Nurtec ODT for you. These are known as contraindications. Nurtec ODT has one contraindication, which is described below.

If you’ve had an allergic reaction: If you’ve had an allergic reaction to Nurtec ODT or any of its ingredients, your doctor likely will not prescribe Nurtec ODT for you. This is because using the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better options for you.

Does Nurtec ODT interact with alcohol?

Nurtec ODT is not known to interact with alcohol. However, alcohol can be a migraine trigger for some people. If it’s a trigger for you, your doctor may recommend that you avoid alcohol or limit the amount you consume.

If you have questions about consuming alcohol with your condition or treatment plan, talk with your doctor or pharmacist.

Drug interactions explained

Learn more about certain drug interactions that can occur with Nurtec ODT.

Interaction with certain antibiotics

Nurtec ODT can interact with certain antibiotics, which are used to treat bacterial infections.

Examples of antibiotics that interact with Nurtec ODT include:

• clarithromycin
• erythromycin (Eryc, others)

What could happen

Certain antibiotics slow down the activity of enzymes that break down Nurtec ODT in your body. This increases the amount of Nurtec ODT in your system. This can raise your risk of side effects from Nurtec ODT, such as nausea or abdominal pain.

What you can do

Your doctor may avoid prescribing certain antibiotics with Nurtec ODT. Instead, they’ll prescribe another antibiotic for your infection that’s safer to take with Nurtec ODT.

But in some cases, your doctor may prescribe Nurtec ODT with an antibiotic it interacts with. If so, they may adjust your dosage schedule for Nurtec ODT. Doing so could help lower your risk of an interaction between these drugs. To learn more about the dosage of Nurtec ODT, see this article.

If you have questions about taking Nurtec ODT with antibiotics, talk with your doctor or pharmacist.

Interaction with certain antiseizure drugs

Nurtec ODT can interact with certain antiseizure drugs, which are used to treat seizures and other conditions.

Examples of antiseizure medications that interact with Nurtec ODT include:

• carbamazepine (Tegretol, others)
• phenytoin (Dilantin)
• cenobamate (Xcopri)

What could happen

Certain antiseizure drugs speed up the action of enzymes and proteins that break down Nurtec ODT in your body. So taking these drugs together can decrease the level of Nurtec ODT in your system, which could make it less effective.

What you can do

Due to this interaction, doctors typically avoid prescribing Nurtec ODT together with an antiseizure drug it interacts with. If you have questions, talk with your doctor or pharmacist.

Are there other interactions with Nurtec ODT?

Nurtec ODT may have other interactions. They could occur with supplements, foods, vaccines, or even lab tests. See below for details. Note that the information below does not include all other possible interactions with Nurtec ODT.

Does Nurtec ODT interact with supplements?

Before you start taking Nurtec ODT, talk with your doctor and pharmacist about any herbs or vitamins and supplements you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions that may affect you, talk with your doctor or pharmacist.

Nurtec ODT interactions with herbs

Nurtec ODT can interact with St. John’s wort, which is used to manage symptoms of depression and other conditions. St. John’s wort can make Nurtec ODT less effective. For this reason, your doctor will likely recommend that you do not take St. John’s wort while taking Nurtec ODT.

If you have questions about taking any herbal supplement product while taking Nurtec ODT, talk with your doctor or pharmacist.

Nurtec ODT interactions with vitamins

There are currently no reports of Nurtec ODT interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

For this reason, it’s still important to check with your doctor or pharmacist before taking any of these products while taking Nurtec ODT.

Does Nurtec ODT interact with food?

Nurtec ODT can interact with grapefruit and grapefruit juice. Grapefruit products can cause your body to break down Nurtec ODT more slowly than usual, which can increase the amount of the drug in your system. This can raise your risk of side effects from Nurtec ODT.

If you consume grapefruit products regularly, you may not need to avoid grapefruit entirely while taking Nurtec ODT. But you should not take more than one dose of the drug within 48 hours of consuming grapefruit. For example, if you use the drug to treat a migraine, your doctor may change your dosing schedule from every day to every other day. If you take Nurtec ODT for preventing a migraine, the dosing schedule is already every other day, so no adjustment is needed. You can learn more about Nurtec ODT’s dosage by reading this article or talking with your doctor or pharmacist.

Before consuming grapefruit or grapefruit juice while taking Nurtec ODT, talk with your doctor or pharmacist.

Does Nurtec ODT interact with vaccines?

There are currently no reports of Nurtec ODT interacting with vaccines. If you have questions about getting certain vaccines during your Nurtec ODT treatment, talk with your doctor.

Does Nurtec ODT interact with lab tests?

There are currently no reports of Nurtec ODT interacting with lab tests. If you have questions about having certain lab tests during your treatment with Nurtec ODT, talk with the healthcare professional ordering the test.

Does Nurtec ODT interact with cannabis or CBD?

There are currently no reports of Nurtec ODT interacting with cannabis (commonly called marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Nurtec ODT.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

Does my health history affect whether I should take Nurtec ODT?

Certain medical conditions or other health factors may raise the risk of interactions with Nurtec ODT. Before using Nurtec ODT, talk with your doctor about your health history. They’ll determine whether Nurtec ODT is right for you.

Health conditions or other factors that might interact with Nurtec ODT include:

End stage renal disease (ESRD) or dialysis: Your kidneys help clear Nurtec ODT from your body. Having a mild, moderate, or even severe kidney problem may not affect whether your doctor prescribes Nurtec ODT for you.

However, if you have end stage renal disease (ESRD) or receive kidney dialysis, they’ll likely prescribe a different migraine treatment for you. It isn’t known whether it’s safe to take Nurtec ODT if these factors apply to you.

Severe liver condition: Nurtec ODT is likely safe to take if you have a mild or moderate liver problem. But if your liver problem is severe, your doctor will likely recommend a different migraine treatment.

Your body relies heavily on the liver to break down Nurtec ODT after you take a dose. A severe liver condition, such as cirrhosis, could cause your body to break down Nurtec ODT too slowly. This could result in high Nurtec ODT levels in your system, which can raise your risk of side effects.

Pregnancy: It’s not known whether Nurtec ODT is safe to use during pregnancy. If you’re pregnant or planning a pregnancy, talk with your doctor before taking Nurtec ODT.

If you do take Nurtec ODT while pregnant, consider enrolling in the drug’s pregnancy registry. This registry collects details about pregnancy issues reported with Nurtec ODT. To learn more, call 1-877-366-0324 or visit the registry website. You can also talk with your doctor for more details.

Breastfeeding: It’s not known whether it’s safe to use Nurtec ODT while breastfeeding. If you’re breastfeeding or planning to do so, talk with your doctor about your options.

Allergic reaction: If you’ve had an allergic reaction to Nurtec ODT or any of its ingredients, your doctor will likely not prescribe Nurtec ODT. This is because using the drug could cause another allergic reaction. You can ask your doctor about other treatments that may be better choices for you.

Common questions about Nurtec ODT and interactions

Find answers to some frequently asked questions about Nurtec ODT and possible interactions.

Can I take Nurtec and Excedrin Migraine together?

There are no reports of Nurtec ODT interacting with acetaminophen/aspirin/caffeine (Excedrin Migraine). Both Nurtec ODT and Excedrin Migraine are used to treat migraine. (Nurtec ODT may also be used to prevent migraine.) Nurtec ODT is only available with a prescription, while Excedrin Migraine is available over the counter (OTC).

In most cases, it should be safe to take these drugs together.

However, if you have a severe liver condition, you should not take Nurtec ODT with Excedrin Migraine. Your body relies on your liver to break down both of these drugs. Having a severe liver condition, such as cirrhosis, could cause your body to break down each drug too slowly. This could result in high levels of the drugs in your system, which can raise your risk of side effects.

Although Excedrin Migraine is available without a prescription, it’s still best to talk with your doctor or pharmacist before using it. The drug may not be safe for you to take if you take certain other medications or have certain conditions, such as severe liver problems.

Talk with your doctor or pharmacist to learn more about how Nurtec ODT and Excedrin Migraine compare and whether you can take these drugs together.

Can I take ibuprofen with Nurtec ODT?

There’s no known interaction between Nurtec ODT and ibuprofen (Advil). Both medications may be used to treat migraine. (Unlike ibuprofen, Nurtec ODT can also be used to prevent migraine.) It should be safe to take these drugs together.

Nurtec ODT is only available with a prescription. Ibuprofen is available OTC, but higher strengths require a prescription.

Although it doesn’t interact with Nurtec ODT, ibuprofen can interact with other medications. It may also not be safe to take if you have certain medical conditions. For this reason, you should talk with your doctor or pharmacist before taking it.

Talk with your doctor or pharmacist if you’d like to learn more about how Nurtec ODT and ibuprofen compare.

Can I take Nurtec ODT and Fioricet together?

Nurtec ODT isn’t reported to interact with butalbital/acetaminophen/caffeine. (Its brand-name version, Fioricet, is no longer available in the United States.) Both medications are used to treat migraine. (Nurtec ODT is also used to prevent migraine.) Doctors are not likely to prescribe these drugs together.

However, butalbital/acetaminophen/caffeine can interact with other medications you take or other conditions you may have.

To learn more about how Nurtec ODT and butalbital/acetaminophen/caffeine compare, talk with your doctor or pharmacist.

Can you take Nurtec ODT with Xanax?

There’s no known interaction between Nurtec and alprazolam (Xanax).

These medications are prescribed for different uses and belong to different groups of drugs. Nurtec ODT is used to treat and prevent migraine. Xanax is used to treat generalized anxiety disorder and panic disorder.

Doctors may prescribe these drugs together (for different conditions), and they should be a safe combination.

To learn more about taking Nurtec ODT with Xanax, talk with your doctor or pharmacist.

How can I prevent interactions?

Taking certain steps can help you avoid interactions with Nurtec ODT. Before starting treatment, talk with your doctor and pharmacist. Things to discuss with them include:

• whether you drink alcohol or use cannabis
• other medications you take, as well as any vitamins, supplements, and herbs (they can also help you fill out a medication list)
• what to do if you start taking a new drug during your Nurtec ODT treatment

It’s also important to understand Nurtec ODT’s label and other paperwork that may come with the drug. Colored stickers that describe interactions may be on the label. And the paperwork (sometimes called the patient package insert or medication guide) may have other details about interactions. (If you did not get paperwork with Nurtec ODT, ask your pharmacist to print a copy for you.)

If you have trouble reading or understanding this information, your doctor or pharmacist can help.

Using Nurtec ODT exactly as prescribed can also help prevent interactions.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

### What is Nurtec ODT?



Nurtec ODT is a medication used to​ treat migraine ⁢headaches. It is​ orally disintegrating, meaning it dissolves on the tongue without the need for water.



### ‌Can you take alcohol while using Nurtec ODT?



It’s generally​ advised to avoid alcohol⁢ while taking Nurtec ODT because⁤ alcohol can potentially ​exacerbate migraine symptoms and interfere⁣ with the ⁣medication’s effectiveness.



### Are there any common medication interactions‍ with Nurtec ODT?



Yes, certain ⁤medications ‌may interact with Nurtec ODT. It is important to inform your ⁢healthcare ‌provider about ‍all the medications you are ⁤currently taking, including prescription and over-the-counter drugs.



### How does ⁣Nurtec ODT ‍interact with other medications?



Nurtec ODT may interact with medications that affect liver enzymes, as⁤ these can ‍change how quickly Nurtec is broken⁣ down⁢ in the ‌body. Always consult your healthcare provider for advice specific⁢ to your medication regimen.



### Can ⁤you take Nurtec ODT‍ with over-the-counter pain relievers?



Some‌ over-the-counter pain relievers might interact with Nurtec ODT. It’s ​best to discuss with your healthcare provider‌ before combining it with other medications.



### Are there any dietary interactions with Nurtec ODT?



There are ⁣no significant dietary restrictions ⁤when taking Nurtec ODT, ‌but maintaining a balanced diet may ‍help manage migraine​ symptoms.



### What ​should I ⁤do if⁢ I experience side effects with Nurtec ODT?



If you experience any side effects while taking Nurtec⁣ ODT, consult your healthcare provider immediately. They can offer guidance ​and adjust your treatment plan if necessary.



### Is ⁤Nurtec ODT suitable⁢ for ⁢everyone?



Nurtec‍ ODT may not be suitable for individuals with certain medical ⁣conditions ‌or those taking specific medications. Always consult with⁢ a⁤ healthcare ​professional to determine if it’s ⁢appropriate for you.